Chorioamnionitis: important risk factor or innocent bystander for neonatal outcome?

Acute Histologic Chorioamnionitis Is a Risk Factor for Adverse Neonatal Outcome in Late Preterm Birth after Preterm Premature Rupture of Membranes

BACKGROUND The objective of this study was to determine whether acute histologic chorioamnionitis is associated with adverse neonatal outcomes in late preterm infants who were born after preterm PROM. METHODOLOGY/PRINCIPAL FINDINGS The relationship between the presence of acute histologic chorioamnionitis and adverse neonatal outcome was examined in patients with preterm PROM who delivered si...

Chorioamnionitis and Patent Ductus Arteriosus: A Systematic Review and Meta-Analysis

BACKGROUND Chorioamnionitis has recently been reported as a risk factor for various neonatal diseases, including cerebral palsy, bronchopulmonary dysplasia, and necrotizing enterocolitis, but its effect on patent ductus arteriosus (PDA) is unclear. We performed a systematic review and meta-analysis to evaluate the effect of chorioamnionitis on PDA. METHODS We searched PubMed, EMBASE, Cochrane...

Chorioamnionitis and neonatal outcome: early vs late preterm infants

Chorioamnionitis (CA) describes an intrauterine status of inflammation and/or infection of placental membranes, refering to both histological and clinical CA [1]. It is considered the major risk of spontaneous preterm delivery, especially at earlier gestational age. The intrauterine exposure to infection/inflammation leads to the fetal inflammatory syndrome (FIRS) that together with CA is respo...

High hematocrit as a risk factor for venous thrombosis. Cause or innocent bystander?

Compliance With a Risk-Factor-Based Guideline for the Prevention of Neonatal Group B Streptococcal Sepsis

OBJECTIVE The purpose of this study was to determine the compliance rate with a maternal risk-factor-based guideline for the prevention of neonatal group B streptococcal (GBS) sepsis. METHODS In August 1994, a risk-factor-based guideline for selective intrapartum prophylaxis against neonatal GBS was adopted by a group model health maintenance organization. This guideline identified the follow...